ABSTRACT
The effect of aspirin on isoproterenol induced changes in lipid metabolism in rats was studied. Aspirin (1.2 mg/100 g/day) was administered orally for a period of 60 days along with/without isoproterenol (20 mg/100g sc twice at a time interval of 24 h for 2 days). Isoproterenol treated rats showed an increase in the levels of heart cholesterol, triglycerides and free fatty acids. The activity of cholesterol ester synthetase CES was increased significantly with concomitant increase in heart lipid peroxide levels in isoproterenol treatment. Aspirin treatment could restore the enzyme activity to near normal and also reduce the level of lipid peroxides. The lipid changes were minimum in rats treated with aspirin and isoproterenol.
Subject(s)
Administration, Oral , Animals , Aspirin/administration & dosage , Cholesterol/metabolism , Fatty Acids, Nonesterified/metabolism , Heart/drug effects , Isoproterenol/administration & dosage , Lipid Metabolism , Male , Myocardium/enzymology , Rats , Rats, Wistar , Sterol Esterase/metabolism , Triglycerides/metabolismABSTRACT
Effect of aspirin (1.2 mg/100 g body wt orally for 30 days) on myocardial infarction induced by isoproterenol (200 mg/kg body wt, subcutaneously for 2 days) has been studied in rats using activities of creatine kinase, aspartate amino transaminase, alanine amino transaminase and lactate dehydrogenase and levels of lipid peroxides as standard markers. Aspirin treatment is found to counteract the effect of isoproterenol on lipid peroxide formation and associated enzyme changes in serum and heart.
Subject(s)
Administration, Oral , Animals , Aspirin/administration & dosage , Creatine Kinase/analysis , Isoproterenol/antagonists & inhibitors , L-Lactate Dehydrogenase/analysis , Lipid Peroxides/analysis , Male , Myocardial Infarction/chemically induced , Myocardium/enzymology , Pilot Projects , Rats , Transaminases/analysisABSTRACT
The effect of isoproterenol on the levels of serum lipoprotein profile were studied in rats. Rats were treated with isoproterenol (200 mg/100 g body weight, sc twice at an interval of 24 hr) for 2 days. Aspirin was administered orally 1.2 mg/100 g body weight, daily for 60 days. Isoproterenol treated rats showed decrease in the activities of hepatic and extrahepatic lipoprotein lipase. HDL cholesterol level was found to be decreased, significantly with increase in LDL cholesterol in isoproterenol treated rats. Aspirin treated rats showed marked reversal of these metabolic changes. The lipoprotein changes were minimum in rats treated with both aspirin and isoproterenol.
Subject(s)
Animals , Aspirin/pharmacology , Isoproterenol , Lipoproteins/blood , Male , Myocardial Infarction/blood , Rats , Rats, Inbred StrainsABSTRACT
The effect of aspirin on isoproterenol-induced changes related to myocardial damage was studied in rats. Rats were treated with aspirin (1.2 mg/100 g/day) orally, daily for a period of one month. Isoproterenol (20 mg/100 g, sc, twice at an interval of 24 hr) was administered. In isoproterenol treated rats marked increase in cholesterol, free fatty acids and triglycerides in both serum and heart were observed. The phospholipid level was lowered in heart with significant increase in serum in isoproterenol treatment. Serum LDL cholesterol was found to be increased with a significant decrease in the level of HDL cholesterol with enhanced level of lipid peroxides in heart. Aspirin showed marked reversal of these metabolic changes induced by isoproterenol.